Lineage-specific expansion of DNA-binding transcription factor families
نویسندگان
چکیده
منابع مشابه
Lineage-specific expansion of DNA-binding transcription factor families
DNA-binding domains (DBDs) are essential components of sequence-specific transcription factors (TFs). We have investigated the distribution of all known DBDs in more than 500 completely sequenced genomes from the three major superkingdoms (Bacteria, Archaea and Eukaryota) and documented conserved and specific DBD occurrence in diverse taxonomic lineages. By combining DBD occurrence in different...
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Transcription factors (TFs) exert their regulatory action by binding to DNA with specific sequence preferences. However, different TFs can partially share their binding sequences. This “redundancy” of binding defines a way of organizing TFs in “motif families” that goes beyond the usual classification based on protein structural similarities. Since the TF binding preferences ultimately define t...
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In bioinformatics, binding of transcription regulatory factors to the cognate binding sites is usually described by sequence-specific binding energy, which is estimated from a training sample of sites. This model implies that all binding sites with binding energy above some threshold are functional and site sequence variations should be considered neutral until they do not reduce this energy be...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2010
ISSN: 0168-9525
DOI: 10.1016/j.tig.2010.06.004