Linagliptin: A thorough Characterization beyond Its Clinical Efficacy
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منابع مشابه
Linagliptin: A thorough Characterization beyond Its Clinical Efficacy
Linagliptin, one of the five dipeptidyl peptidase-4 inhibitors available, has recently entered the market both in the US and in most European countries for treatment of type 2 diabetes mellitus. It presents a xanthine-based structure, and is characterized by unique pharmacokinetics, with non-linear profile, long terminal half-life allowing prolonged exposure to the drug. It is eliminated predom...
متن کاملThe clinical application of linagliptin in Asians
Asia has a growing diabetic population. Linagliptin, a member of dipeptidyl peptidase-4 inhibitor class, is unique in its nonlinear pharmacokinetics with the characteristics of rapid attainment of steady state, little accumulation, predominantly nonrenal route of elimination, prolonged terminal half-life, and sustained inhibition of dipeptidyl peptidase-4 enzyme. No clinically relevant differen...
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Type 2 diabetes mellitus (T2DM) has a high prevalence and incidence around the world. The complex pathophysiology mechanism is among the barriers for diabetes treatment. Type 2 diabetes patients have dysfunction in incretin hormones (as glucagon-like peptide-1 or GLP-1, and glucose-dependent insulinotropic polypeptide or GIP). By inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme, it is possi...
متن کاملHow Thorough Is Thorough Enough?
Abstraction is the key for effectively dealing with the state explosion problem in model-checking. Unfortunately, finding abstractions which are small and yet enable us to get conclusive answers about properties of interest is notoriously hard. Counterexample-guided abstraction refinement frameworks have been proposed to help build good abstractions iteratively. Although effective in many cases...
متن کاملClinical utility and tolerability of linagliptin in diabetic patients
BACKGROUND The purpose of this paper is to review the efficacy, safety, and tolerability of linagliptin in the management of hyperglycemia in adults with type 2 diabetes mellitus. METHODS A Medline search was performed using the keywords "linagliptin" and "type 2 diabetes" for articles published September 2010 through July 2012. The literature search was limited by the following criteria: art...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2013
ISSN: 1664-2392
DOI: 10.3389/fendo.2013.00016