LIN-28 balances longevity and germline stem cell number inCaenorhabditis elegansthrough let-7/AKT/DAF-16 axis
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منابع مشابه
LIN‐28 balances longevity and germline stem cell number in Caenorhabditis elegans through let‐7/AKT/DAF‐16 axis
The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28-regulated microRNA let-7 wa...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2016
ISSN: 1474-9718
DOI: 10.1111/acel.12539