Limited sampling strategy for determining metformin area under the plasma concentration-time curve
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چکیده
منابع مشابه
A limited sampling strategy for estimating sirolimus area-under-the-concentration curve.
Area-Under-the-Concentration Curve, Bruce Kaplan,* Herwig-Ulf Meier-Kriesche, Kimberly Napoli, and Barry D. Kahan (Div. of Renal Dis. and Hypertension, Dept. of Internal Med., and Div. of Immunol. and Organ Transplant., Dept. of Surgery, The University of Texas Medical School at Houston, 6431 Fannin, Suite 4.163, Houston, TX 77030; *author for correspondence and reprint requests: fax 713-794-1197)
متن کاملLimited sampling model for area under the concentration time curve of total topotecan.
Antitumor activity of topotecan, a new derivative of camptothecin, has been documented in many tumors. The active lactone form of topotecan is in equilibrium with the inactive hydroxyacid form. However, dose-limiting toxicity, neutropenia, is correlated to the area under the concentration time curve (AUC) of not only the lactone form but also total (lactone + hydroxyacid) topotecan. Because the...
متن کاملLimited Sampling Strategies to Estimate the Area under the Concentration-time Curve
H. Tsuruta1; M. Fukumoto2; L. Bax3; A. Kohno4; Y. Morishita4 1Department of Medical Informatics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan; 2Division of Toxicology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan; 3Pharsight Corporation, Sunnyvale, CA, USA; 4Department of Hematology and Oncolog...
متن کاملLimited sampling strategies to estimate the area under the concentration-time curve. Biases and a proposed more accurate method.
BACKGROUND Over 100 limited sampling strategies (LSSs) have been proposed to reduce the number of blood samples necessary to estimate the area under the concentration-time curve (AUC). The conditions under which these strategies succeed or fail remain to be clarified. OBJECTIVES We investigated the accuracy of existing LSSs both theoretically and numerically by Monte Carlo simulation. We also...
متن کاملLimited sampling model for the area under the concentration versus time curve of irinotecan and its application to a multicentric phase II trial.
We previously established a limited sampling model (LSM) for the area under the concentration versus time curve (AUC) of irinotecan (CPT-11). Using this LSM, we performed a pharmacokinetic-pharmacodynamic analysis of CPT-11 in a multicentric Phase II study for non-small cell lung cancer. Ten institutes participated in this study, 36 patients were registered, and 30 patients were evaluable for t...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2016
ISSN: 0306-5251
DOI: 10.1111/bcp.13049