Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE−/− Reporter Mouse

Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE−/− Reporter Mouse—Brief Report

OBJECTIVE To create a model of atherosclerosis using green fluorescent protein (GFP)-targeted monocytes/macrophages, allowing analysis of both endogenous GFP+ and adoptively transferred GFP+ myeloid cells in arterial inflammation. APPROACH AND RESULTS: hCD68GFP reporter mice were crossed with ApoE-/- mice. Expression of GFP was localized to macrophages in atherosclerotic plaques and in angioten...

Mobile complex atherosclerotic aortic plaque.

To cite: Bajaj R, Chhabra L, Kruger M, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013009542 DESCRIPTION A 64-year-old man with a history of paroxysmal atrial fibrillation (AF) and transient ischaemic attack was admitted with complaints of palpitations and fatigue. He was found to be having AF with sustained rapid ventricular response. He had failed ra...

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

Inflammation drives atherosclerotic plaque progression and rupture, and is a compelling therapeutic target. Consequently, attenuating inflammation by reducing local macrophage accumulation is an appealing approach. This can potentially be accomplished by either blocking blood monocyte recruitment to the plaque or increasing macrophage apoptosis and emigration. Because macrophage proliferation w...

Monocyte recruitment and macrophage proliferation in atherosclerosis.

Copyright © Polskie Towarzystwo Kardiologiczne INTRODUCTION In the famous ‘Atlas of atherosclerosis: progression and regression’, Herbert Stary [1] outlines in remarkable detail the development of human atherosclerosis. The photographs depicting lesions at all stages of development, from newborns to the elderly, capture in stunning detail the complexity of an evolving disease. Type I lesions de...