Limited clinical value of exhaled volatile organic compound measurements in childhood asthma
نویسندگان
چکیده
منابع مشابه
Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study.
The hypothesis was that prediction of asthma exacerbations in children is possible by profiles of exhaled volatile organic compounds (VOCs), a noninvasive measure of airway inflammation. The aims of the present study were to determine: 1) whether VOCs in exhaled breath are able to predict asthma exacerbations; and 2) the time course and chemical background of the most predictive VOCs. A prospec...
متن کاملBreath measurements as volatile organic compound biomarkers.
A brief review of the uses of breath analysis in studies of environmental exposure to volatile organic compounds (VOCs) is provided. The U.S. Environmental Protection Agency's large-scale Total Exposure Assessment Methodology Studies have measured concentrations of 32 target VOCs in the exhaled breath of about 800 residents of various U.S. cities. Since the previous 12-hr integrated personal ai...
متن کاملNon-invasive phenotyping using exhaled volatile organic compounds in asthma.
BACKGROUND Breath volatile organic compounds (VOCs) may be useful for asthma diagnosis and phenotyping, identifying patients who could benefit from personalised therapeutic strategies. The authors aimed to identify specific patterns of breath VOCs in patients with asthma and in clinically relevant disease phenotypes. METHODS Breath samples were analysed by gas chromatography-mass spectrometry...
متن کاملDefining adult asthma endotypes by clinical features and patterns of volatile organic compounds in exhaled air
BACKGROUND Several classifications of adult asthma patients using cluster analyses based on clinical and demographic information has resulted in clinical phenotypic clusters that do not address molecular mechanisms. Volatile organic compounds (VOC) in exhaled air are released during inflammation in response to oxidative stress as a result of activated leukocytes. VOC profiles in exhaled air cou...
متن کاملChildhood asthma: exhaled nitric oxide in relation to clinical symptoms.
Bronchial asthma is associated with increased levels of exhaled nitric oxide which are suppressible by glucocorticosteroid inhalation. Children with bronchial asthma were studied to elucidate the relation between endogenous NO release and recent symptoms of bronchial obstruction. Twenty-five children with atopic asthma and 11 healthy control subjects were enrolled and exhaled NO was studied usi...
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ژورنال
عنوان ژورنال: ERJ Open Research
سال: 2018
ISSN: 2312-0541
DOI: 10.1183/23120541.00026-2018