Limitations of AST/ALT ratio in paracetamol poisoning
نویسندگان
چکیده
منابع مشابه
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning?
CONTEXT Paracetamol (acetaminophen or APAP) is the most common pharmaceutical exposure in the US. Elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels indicate hepatic toxicity. AST and ALT levels rise in similar proportions but later decline at different rates, with AST falling more rapidly than ALT. OBJECTIVE To determine whether the AST/ALT ratio can ind...
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West Midlands Centre for Adverse Drug Reactions, City Hospital, Birmingham, UK School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK National Poisons Information Service, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK University/BHF Centre for Cardiovascular Science, Edinburgh University, Queen’s Medical Research Ins...
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A 15 year old girl was admitted 55 hours after taking an unspecified quantity of paracetamol. She was fully conscious and oriented. Her pulse rate was 88 beats/ min regular and blood pressure 110/70 mm Hg. The liver edge was palpable and tender. Plasma paracetamol concentration was 41 mg/I, serum sodium concentration 138 mmol/l, serum potassium concentration 4-2 mmol/l, plasma urea concentratio...
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Of 41 cases of acute paracetamol poisoning one died of gastrointestinal haemorrhage and acute massive necrosis of the liver, three became jaundiced, and 13 others had biochemical evidence of hepatocellular damage. Liver damage is a toxic effect which is present in most patients who ingest more than 15 g. of paracetamol. One patient with liver damage survived renal failure due to acute tubular n...
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Every physician is only too familiar with acute failure, and who showed histological features consistent with toxic myocarditis, such as diffuse myocardial hepatic necrosis as the most common complication of severe paracetamol poisoning. The frequency with damage with interstitial oedema or bands of necrosis and haemorrhage.10,11,13–15 It is likely that other which paracetamol is used for self-...
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ژورنال
عنوان ژورنال: Clinical Toxicology
سال: 2015
ISSN: 1556-3650,1556-9519
DOI: 10.3109/15563650.2015.1027904