Light chain amyloidosis presenting as retiform purpura
نویسندگان
چکیده
منابع مشابه
Light Chain Amyloidosis
Light chain (AL) amyloidosis is caused by a usually small plasma-cell clone that is able to produce the amyloidogenic light chains. They are able to misfold and aggregate, deposit in tissues in the form of amyloid fibrils and lead to irreversible organ dysfunction and eventually death if treatment is late or ineffective. Cardiac damage is the most important prognostic determinant. The risk of d...
متن کاملMultiple myeloma-associated light chain amyloidosis presenting as verrucous lingual masses.
Sir, Multiple myeloma is a monoclonal B-cell neoplasm, which is characterized by autonomous proliferation of immunoglobulin-secreting plasma cells, capable of synthesizing amyloidogenic light chains (AL). AL amyloidosis is characterized by extracellular deposition of eosinophilic, homogeneous, amorphous material composed of fibrillary protein, containing light chain fragments (1). The oral clin...
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BACKGROUND We present a case of amyloid light-chain amyloidosis with occult plasma cell dyscrasia, with the rare initial presentation of gastroparesis. While amyloidosis is known to affect the gastrointestinal system, rarely do patients present with gastrointestinal symptoms as their first symptom. To the best of our knowledge, this is the first such case reported with a definitive diagnosis ma...
متن کاملSenile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis.
BACKGROUND Small deposits of amyloid are often found in the hearts of elderly patients. However, extensive deposition of transthyretin-derived amyloid fibrils in the heart (senile systemic amyloidosis [SSA]) can cause heart failure. The clinical features of SSA that involve the heart are ill defined, and the condition may be overlooked as a cause of heart failure. We sought to better define the...
متن کاملAtypical immunoglobulin light chain amyloidosis
BACKGROUND Primary immunoglobulin light chain amyloidosis (AL amyloidosis) is a plasma cell disorder which mainly affects heart, kidneys, liver, and peripheral nervous system. Cases of atypical AL amyloidosis presented as spontaneous vertebral compression fractures have been rarely reported, and data about the management and clinical outcomes of the patients are scarce. METHODS Herein, we pre...
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ژورنال
عنوان ژورنال: JAAD Case Reports
سال: 2021
ISSN: 2352-5126
DOI: 10.1016/j.jdcr.2021.03.051