Ligand-Selective Targeting of the Glucocorticoid Receptor to Nuclear Subdomains Is Associated with Decreased Receptor Mobility

Ligand-selective targeting of the glucocorticoid receptor to nuclear subdomains is associated with decreased receptor mobility.

The association between nuclear distribution and mobility of the human glucocorticoid receptor was examined in living COS-1 cells using yellow fluorescent protein- and cyan fluorescent protein-tagged receptors. Quantitation of the nuclear distribution induced by an array of glucocorticoid ligands revealed a continuum from a random (cortisone) to a nonrandom (triamcinolone acetonide) receptor di...

Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling.

Glucocorticoids are stress hormones that maintain homeostasis through gene regulation mediated by nuclear receptors. We have discovered that other cellular stressors are integrated with glucocorticoid signaling through a new hormone-independent phosphorylation site, Ser134, on the human glucocorticoid receptor (GR). Ser134 phosphorylation is induced by a variety of stress-activating stimuli in ...

Patterns of exposure to glucocorticoid receptor ligand.

Hormones are characteristically secreted in distinct pulses. Corticosterone (in rodents) and cortisol (in human) show profound circadian and ultradian rhythmicity which results in rapid changes in ligand concentration in the circulating blood. The pattern of ultradian glucocorticoid levels shows genetic modulation, can change according to the physiological and pathological status of the animal ...

Decreased hippocampal mineralocorticoid / glucocorticoid receptor ratio is associated with low - birth 1 weight in female

Decreased hippocampal mineralocorticoid/glucocorticoid receptor ratio is associated with low-birth 1 weight in female Cynomolgus macaque neonates 2 3 Shirlene X Ong, Keefe Chng, Michael J Meaney , Jan P Buschdorf 4 Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), 5 Singapore, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 11760...

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age