Lifespan and testosterone

Exogenous Testosterone, Finasteride and Castration Effects on Testosterone, Insulin, Zinc and Chromium in Adult Male Rats

Background: Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. Methods: Male adu...

Toxicity and lifespan extension

The RB pathway is one of the best-studied and most frequently altered pathways leading to loss of proliferative control in cancer. it can be disrupted by a variety of means including, but not limited to, epigenetic silencing, allelic loss or mutation of RB1. in some cancers including breast cancer, amplification of the CCND1 gene or overexpression of cyclin D1 is commonly observed.1 in others, ...

Macronutrient balance and lifespan

Dietary restriction (DR) without malnutrition is widely regarded to be a universal mechanism for prolonging lifespan. It is generally believed that the benefits of DR arise from eating fewer calories (termed caloric restriction, CR). Here we argue that, rather than calories, the key determinant of the relationship between diet and longevity is the balance of protein to non-protein energy ingest...

Surname Frequency and Lifespan

Using administrative records from the Social Security Administration this article explores the relationship between surname frequency and lifespan for over 19 million people born in 1910-19 and deceased by 2011—which represent over 80% of the total population born in 191019. People with more frequent surnames had shorter average and median lifespans. Differences in average lifespan between the ...

Running Head: TESTOSTERONE AND POWER Testosterone and power