Lidocaine and Mexiletine Therapy for Erythromelalgia
نویسندگان
چکیده
منابع مشابه
Lidocaine and mexiletine therapy for erythromelalgia.
A 25-YEAR-OLDwhitemanpresentedwithalifelong history of severe, sometimes excruciatingpain inhis legs,whichwereconstantly red and hot. He insisted on having his legs and feet constantly in ice water to relieve his severe discomfort. He required treatment with oxycodone and acetaminophen (Percocet) every 4 hours for pain. His mother recalled that from the age of 2 years his feet and legs intermit...
متن کاملPrimary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment.
Erythromelalgia is a rare, chronic, debilitating condition characterized by redness, warmth, and severe burning pain of the distal extremities. The feet are more commonly affected than the hands. Pain is precipitated by increases in temperature and by exercise. Patients often obtain relief by immersing the affected extremity in cold water. The pain is often refractory to treatment. For many pat...
متن کاملLidocaine patch for pain of erythromelalgia.
A 15-year-old white girl had continuous mild discomfort associated with coolness and slight cyanosis of both feet. Intermittently, whenever she exercised, her feet became bright red and extremely painful, consistent with intermittent episodes of erythromelalgia (Figure 1). The discomfort markedly affected her daily activities: she stopped hiking, playing sports, marching in the high school band...
متن کاملLidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.
BACKGROUND Accumulating evidence suggests that mitochondrial rather than sarcolemmal adenosine triphosphate-sensitive K+ (K(ATP)) channels may have an important role in the protection of myocardium during ischemia. Because both lidocaine and mexiletine are frequently used antiarrhythmic drugs during myocardial ischemia, it is important to investigate whether they affect mitochondrial K(ATP) cha...
متن کاملErythromelalgia: studies on pathogenesis and therapy
Erythromelalgia (EM) is a rare condition characterized by red, hot and painful extremities. Local skin cooling provides relief. Warmth, exercise and dependency of the extremity intensify the discomfort. Shunt hypothesis: Clinical observations and pathophysiological findings are compatible with microvascular arteriovenous shunting of blood as a final common pathway of pathogenesis of erythromela...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 1999
ISSN: 0003-987X
DOI: 10.1001/archderm.135.12.1447