LH-RH-Receptor interaction is inhibited by Des-His-2-Des-Gly-10-LH-RH-ethylamide
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چکیده
منابع مشابه
Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH.
The mechanisms through which LH-RH antagonists suppress gonadotroph functions and LH-RH receptor (LH-RH-R) production are incompletely understood. To elucidate these mechanisms, we investigated the effects of Cetrorelix on the mRNA expression of pituitary LH-RH-R and luteinizing hormone (LH) secretion in three experimental systems with different pituitary LH-RH environments. Ovariectomy induced...
متن کاملDown-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.
Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. [Ac-D-Nal(2)1,D-Ph(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH-R H (SB-75; Cetrorelix) is a modern, potent antagonistic analog of LH-RH. In this study, the binding characteristics of receptors for L...
متن کاملLH-RH neuron system of the newt by immunohistochemical study.
The location of LH-RH producing neurons, the pathways and terminal distributions of their fibers in the newt, Cynops pyrrhogaster were studied immunohistochemically. The LH-RH positive perikarya are located in the nucleus of the diagonal band of Broca and the medial septal nucleus. No LH-RH immunoreactive neuronal perikarya could be detected in the diencephalon. The pathways of fibers originati...
متن کامل3 H-labelling of a synthetic decapeptide having LH and FSH releasing activity (LH-RH--FSH-RH).
A decapeptide capable to stimulate the release of LH and FSH from pituitary has been recently isolated from hypothalami of porcine origin and its amino acid sequence has been established as (Pyro)Glu-HisTrp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH, [ 1,2]. An identical decapeptide has been found in sheep hypothalami [ 3,4] . Several laboratories described syntheses of LH-RH/FSH-RH either by the solid pha...
متن کاملMotility, mitochondrial membrane potential and ATP content of rabbit spermatozoa stored in extender supplemented with GnRH analogue [des-Gly10, D-Ala6]-LH-RH ethylamide.
The present study was aimed to determine the effect of GnRH analogue [des-Gly10, D-Ala6]-LH-RH ethylamide on the quality of rabbit spermatozoa stored at 17°C for 3 days. Semen from 5 bucks (13 ejaculates) was used in the experiment. Ejaculates were divided and diluted at a 1:10 ratio with rabbit semen extender Galap (IMV, France) (Control) or with Galap extender supplemented with GnRH analogue ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1974
ISSN: 0014-5793
DOI: 10.1016/0014-5793(74)81069-0