LGL Can Partition the Cortex of One-Cell Caenorhabditis elegans Embryos into Two Domains
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LGL Can Partition the Cortex of One-Cell Caenorhabditis elegans Embryos into Two Domains
Many metazoan cell types are polarized by asymmetric partitioning of the conserved PAR (PAR-3/PAR-6/PKC-3) complex. Cortical domains containing this PAR complex are counterbalanced by opposing domains of varying composition. The tumor-suppressor protein LGL facilitates asymmetric localization of cell fate determinants, in part through modulating the activity of the PAR complex. However, the mec...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2010
ISSN: 0960-9822
DOI: 10.1016/j.cub.2010.05.061