منابع مشابه
Efficacy of levetiracetam in partial seizures.
Controlled clinical trials and routine clinical practice demon-strate that levetiracetam is effective as add-on therapy and appears to allow for withdrawal to monotherapy in patients who respond well in the add-on setting. In pivotal clinical trials of adjunctive therapy with levetiracetam 1000 to 3000 mg/day (pooled data), 40% to 54% of patients experienced a 50% or greater reduction in seizur...
متن کاملPharmacokinetics of levetiracetam in neonates with seizures.
The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.
متن کاملLevetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats
Despite anticonvulsant efficacy in animal models of generalized epilepsy, levetiracetam was not effective in the maximal subcutaneous PTZ model in mice and rats. Aim of this study was to assess the efficacy of levetiracetam (LEV) against submaximal, s.c. MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA). Thirty male Wistar rats (P42) were...
متن کاملUse of Levetiracetam in Prophylaxis of Early Post-Traumatic Seizures.
AIM Traumatic brain injury is one of the leading causes of mortality and morbidity worldwide. The role of prophylactic anti-epileptic drugs has been established. Phenytoin used traditionally for this purpose carries a burden of adverse reactions and cumbersome need of monitoring and maintaining levels in serum. Therefore, as the evidence on levetiracetam, emerged part of neurosurgery section st...
متن کاملLevetiracetam in the treatment of neonatal seizures: A pilot study
PURPOSE At present, neonatal seizures are usually treated with Phenobarbital (PB) despite the limited efficacy and the potential risk this treatment holds for the developing brain. We report here a prospective pilot feasibility study on the use of Levetiracetam as monotherapy in the treatment of neonatal seizures. METHODS Six newborns (body weight>2000 g, gestational age>30 weeks) presenting ...
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ژورنال
عنوان ژورنال: Clinical Toxicology
سال: 2017
ISSN: 1556-3650,1556-9519
DOI: 10.1080/15563650.2017.1355056