Leukotrienes and other Lipoxygenase Products
نویسندگان
چکیده
منابع مشابه
5-lipoxygenase-derived leukotrienes: mediators also of atherosclerotic inflammation.
Atherogenesis is now viewed as the outcome of hypercholesterolemia in combination with inflammation of the vessel wall; an intertwined sequence of events leads to fatty streaks, which may develop to atherosclerosis.1 Several recent studies have implicated lipoxygenases in this process. Mammalian lipoxygenases have two principal functions.2 One is to modify membranes by peroxidation reactions; 1...
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Rainbow trout macrophages maintained in short term culture when incubated with either calcium ionophore, A23187, or opsonized zymosan synthesize a range of lipoxygenase products including lipoxins and leukotrienes. These cells are unusual in that they generate more lipoxin than leukotriene following such challenge. The main lipoxin synthesized was lipoxin (LX) A4. This compound was identified b...
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ON THE COVER Calderon et al. show that the pancreas has the unique feature of having macrophages from different lineages in distinct anatomical sites. The cover image illustrates that pancreatic islet macrophages derive from defi nitive hematopoiesis (orange), whereas stromal macrophages are of mixed origin, deriving from both defi nitive (orange) and primitive (green) hematopoiesis. Artwork by...
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Human platelet-type 12-lipoxygenase (12-LOX) has recently been shown to play an important role in regulation of human platelet function by reacting with arachidonic acid (AA). However, a number of other fatty acids are present on the platelet surface that, when cleaved from the phospholipid, can be oxidized by 12-LOX. We sought to characterize the substrate specificity of 12-LOX against six ess...
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The development of atherosclerosis is accelerated in individuals with type 2 diabetes. Adhesion of monocytes to the vascular endothelium is a key initial step in atherogenesis. We have previously shown that monocyte adhesion to human aortic endothelial cells (HAECs) cultured long-term in high-glucose medium (25 mmol/L, 2 passages) is increased compared with cells grown in normal glucose (5 mmol...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1983
ISSN: 0014-5793
DOI: 10.1016/0014-5793(83)80053-2