Leukotriene C4 induces vasogenic cerebral edema in rats
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چکیده
منابع مشابه
Leukotriene C4 induces vasogenic cerebral edema in rats.
Materials and Methods. Wistar rats weighing 434 to 478 g were anesthetizedith ketamine (87 mg/kg) and xylazine (13 mg/kg) injected intramuscularly. PE-10 polyethylene catheters were inserted into the femoral artery and vein. The arterial catheter was connected to a blood pressure transducer and systemic arterial blood pressure was continuously imonitored. Buffered evans blue (0.75 ml) was injec...
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Leukotrienes are pharmacologically active compounds that promote vascular permeability. In this study we sought to determine whether tissue leukotriene-like immunoreactivity was increased in intracranial tumors associated with peritumoral edema. In 20 patients undergoing craniotomy tissue specimens were immediately frozen after removal and tissue leukotriene C4 levels were determined by radioim...
متن کاملBrain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: leukotriene C4 as a possible cause of cerebral edema.
The relation of brain eicosanoids to progression of cerebral edema was studied in stroke-resistant spontaneously hypertensive rats subjected to incomplete global brain ischemia induced by bilateral occlusion of the common carotid arteries. Thromboxane B2 and 6-keto prostaglandin F1 alpha levels were significantly elevated 5 minutes after reperfusion but returned to control levels by 30 minutes....
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The effects on eicosanoid levels were investigated in the stroke-resistant spontaneously hypertensive rat (SHRSR) brain and the relation of eicosanoid to the progression of cerebral edema was studied. The effects of dexamethasone, indomethacin and AA-861 on the induction of eicosanoids and cerebral edema were also studied in this model. Global cerebral ischemia was induced by occluding the bila...
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Brain edema (BE) research lacks quantitative regional methods. We modified the method of Pappius and McCann (1969), who used radioactive iodinated P serum albumin (R1SA) as a label for vasogenic BE fluid. To correct for intravascular plasma volume we used Cr^ labelled red blood cells and calculated equivalent extravascular plasma volume (EVPV). The modified RISA method was compared with a stand...
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ژورنال
عنوان ژورنال: Prostaglandins, Leukotrienes and Medicine
سال: 1984
ISSN: 0262-1746
DOI: 10.1016/0262-1746(84)90117-3