Leukemic IL‐17RB signaling regulates leukemic survival and chemoresistance

Inhibition of Cyclin-dependent Kinase (CDK) Decreased Survival of NB4 Leukemic Cells: Proposing a p53-Independent Sensitivity of Leukemic Cells to Multi-CDKs Inhibitor AT7519

An unbounded number of events exist beneath the intricacy of each particular hematologic malignancy, prompting the tumor cells into an unrestrained proliferation and invasion. Aberrant expression of cyclin-dependent kinases (CDKs) is one of these events which disrupts regulation of cell cycle and subsequently, results in cancer progression. In this study, we surveyed the repressive impact of mu...

Letter: Leukemic meningitis in acute leukemic adults.

Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells

The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to growth of human leukemic cell lines and mouse T-cell acute leukemia (T-ALL) c...

Inhibition of Cyclin-dependent Kinase (CDK) Decreased Survival of NB4 Leukemic Cells: Proposing a p53-Independent Sensitivity of Leukemic Cells to Multi-CDKs Inhibitor AT7519

An unbounded number of events exist beneath the intricacy of each particular hematologic malignancy, prompting the tumor cells into an unrestrained proliferation and invasion. Aberrant expression of cyclin-dependent kinases (CDKs) is one of these events which disrupts regulation of cell cycle and subsequently, results in cancer progression. In this study, we surveyed the repressive impact of mu...

Predicting survival and leukemic evolution in patients with myelodysplastic syndrome.

Malignant Lymphomas 1605-1612 The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma Tomás Álvaro, Marylène Lejeune, Francisca I. Camacho, Maria Teresa Salvadó, Lydia Sánchez, Juan F. García, Carlos Lopez, Joaquín Jaén, Ramón Bosch, Lluis E. Pons, Carmen Bellas, Miguel A. Piris Thrombosis 1613-1620 Lipoprotein(a), fibrinoge...