Leukemias Resembling Acute Promyelocytic Leukemia, Microgranular Variant

Hematopathology / LEUKEMIAS RESEMBLING ACUTE PROMYELOCYTIC LEUKEMIA, MICROGRANULAR VARIANT Leukemias Resembling Acute Promyelocytic Leukemia, Microgranular Variant

Acute promyelocytic leukemia (APL) should be distinguished from other subtypes of acute myeloid leukemia (AML) because of the increased risk of disseminated intravascular coagulation (DIC) and its response to arsenic compounds and retinoids. Some cases of AML seem morphologically similar to the microgranular variant of APL (French-AmericanBritish [FAB] AML-M3v) but lack the t(15;17). We evaluat...

Acute promyelocytic leukemia microgranular variant – A clinical and therapeutical approach

Acute promyelocytic leukemia (APL) is a rare form of acute myeloid leukemia with a particular diagnosis and therapeutic approach. APL represents only 10-15% of acute myeloid leukemia in adults. The median diagnosis age is around 40 years. APL’s main genetic event is the translocation between chromosome 15 and chromosome 17 – t(15;17)(q22;q21) – generating the PML-RARα fusion gene. APL has four ...

Down syndrome with microgranular variant of acute promyelocytic leukemia in a child: a case report

BACKGROUND Acute promyelocytic leukemia (APL) accounts for less than 10% of pediatric AML. Cases of APL in Down syndrome (DS) have been described in the literature rarely and it is rarer still to find the microgranular variant (M3v) of APL in trisomy 21 patients. CASE PRESENTATION We present a case of a five-year-old female with Down syndrome diagnosed with acute promyelocytic leukemia (APL)....

Myeloid natural killer cell leukemia resembling a variant of acute promyelocytic leukemia.

A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.

Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative geno...