Leucocyte adhesion deficiency.

Non-Hodgkin's lymphoma in a patient with leucocyte adhesion deficiency.

Leucocyte adhesion deficiency presenting as a chronic ileocolitis.

CD11/CD18 leucocyte glycoprotein deficiency is a rare, congenital adhesion molecule disorder which, in its severe form, is usually fatal. Leucocytes in affected subjects have abnormal migration and adherence, rendering patients susceptible to life threatening infections. The CD11/CD18 integrins, and other adhesion molecules, are considered essential to the normal inflammatory response. It has b...

Leucocyte adhesion defect-1.

Leucocyte adhesion defect (LAD) is an inherited disorder of phagocytic function. It is characterized by inability of the leucocytes, in particular neutrophilis to migrate from the blood stream towards sites of inflammation. LAD -1 is characterized by the absence of b 2 integrins (CD 11 / CD18) on leucocytes. This disorder is characterized by delayed separation of the umbilical cord, recurrent s...

leucocyte-endothelial cell adhesion in intestinal inflammation

Background-An important action of interleukin 8 (IL8) is stimulation ofgranulocytes. The object of this study was to assess the contribution ofIL8 to the leucocyte-endothelial celi interactions associated with intestinal inflammation in the rat. Methods-Two indomethacin injections (48 and 24 hours prior to the experiments) induced a longlasting ileitis in rats. The number of adherent and emigra...

Leukocyte Adhesion Deficiency Type 1 Presenting as Leukemoid Reaction

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...