منابع مشابه
The hypotensive activity and side effects of methyldopa, clonidine, and guanfacine.
Clonidine (Catapres, Catapresan), guanfacine (Estulic), and methyldopa (Aldomet) are the prototypes of centrally acting antihypertensive drugs. Clonidine and guanfacine are lipophilic drugs that readily penetrate into the brain, where they stimulate alpha-adrenergic receptors in the pontomedullary region. The stimulation of these central alpha-adrenergic receptors has been shown to activate an ...
متن کاملHypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone in treatment of hypertension.
In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during...
متن کاملEvaluation of Awareness, Performance and Side Effects of Formaldehyde Exposure
Background and purpose: Formaldehyde is used in operating rooms to disinfect and sterilize surgical instruments. Inhalation of formaldehyde gas causes various respiratory complications in people. Awareness on the use of formaldehyde can prevent many complications. This study was conducted to determine the level of knowledge and practice about formaldehyde exposure in the staff and students of t...
متن کاملEffects of Maternal Alpha Methyldopa Administration on Memory of Rat Offspring during Growing Age
Background: Alpha Methyldopa (AMD) is a well-known treatment for the pregnancy induced hypertension and commonly used in several countries. Indeed the possible effect of AMD on the behavioral activities of offspring, whom are exposed during fetus period, has not been studied. The present study evaluated the possible effect of maternal administration of AMD on the rat offspring memory in the gro...
متن کاملAntihypertensive Metabolites of a-Methyldopa
a-Methyldopa acts through a metabolite in the central nervous system. Of the three metabolites most prominently considered as potential mediators of a-methyldopa hypotension — amethyldopamine, a-methylnorepinephrine (MNE), and a-methylepinephrine (ME) — ME is the most potent depressor agent following intravenous infusion into rats, following injection into the lateral ventricle, and following i...
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ژورنال
عنوان ژورنال: BMJ
سال: 1975
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5969.501-a