منابع مشابه
deoxyuridine suppression test . New micro method for
The deoxyuridine suppression (dU) test measures the effect of deoxyuridine in suppressing the uptake of radioactively labelled tritiated thymidine into DNA and is specifically abnormal in vitamin B12 or folate deficiency, or when the metabolism of these is disturbed. The test is based on the observation that bone marrow cells from patients deficient in vitamin B12 incorporated much more thymidi...
متن کاملDetection of folate deficiency in alcoholism using the peripheral blood lymphocyte deoxyuridine suppression test.
Twenty-seven alcoholic patients were studied for folate status. Twenty-two (81%) had neutrophil hypersegmentation and were detected as folate deficient by also having low serum folate, erythrocyte folate, lymphocyte folate and/or an abnormal peripheral blood lymphocyte deoxyuridine suppression test. Seventeen (63%) had an abnormal lymphocyte deoxyuridine suppression test and all 17 were correct...
متن کاملAssessment of deoxyuridine suppression test in diagnosis of vitamin B12 or folate deficiency.
Deoxyuridine (dU) suppression tests have been performed on virtually all marrow samples aspirated at this hospital over the past 12 months. Of the 110 samples studied 26 gave abnormal results, and these 26 samples came from patients deficient in either vitamin B(12) or folate. The dU suppression test was found to be of particular value in the diagnosis of vitamin B(12) or folate deficiency in n...
متن کاملDeoxyuridine suppression test: a comparison of two methods and effect of thymidine on the incorporation of 3H-deoxyuridine into DNA in human bone marrow cells.
Deoxyuridine suppression tests have been performed by two different methods of six normoblastic and eight megaloblastic marrows. A good correlation was obtained between the results by the modified and the original methods. The simplified method was found to be applicable for a clinical purpose to diagnose megaloblastosis in the marrow. Uptake of 3H-deoxyuridine into DNA and effect of various co...
متن کاملEffect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency.
In vitro, deoxyuridine (dU) failed to block the incorporation of 3H-thymidine into bone marrow from 11 cases of vitamin B,2 deficiency, 6 cases of folate deficiency, an’i 3 cases of combined deficiency, even in patients without overt anemia, macrocytosis, and/or megaloblastosis. Different folate and cobalamin compounds had different effects on the incorporation of 3H-thymidine in the two defici...
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ژورنال
عنوان ژورنال: BMJ
سال: 1975
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5962.87-b