Lethality and centrality in protein networks
نویسندگان
چکیده
منابع مشابه
Functional centrality: detecting lethality of proteins in protein interaction networks.
Identifying lethal proteins is important for understanding the intricate mechanism governing life. Researchers have shown that the lethality of a protein can be computed based on its topological position in the protein-protein interaction (PPI) network. Performance of current approaches has been less than satisfactory as the lethality of a protein is a functional characteristic that cannot be d...
متن کاملGene networks from DNA microarray data: centrality and lethality
We construct a gene network based on expression data from DNA microarray experiments, by establishing a link between two genes whenever the Pearson’s correlation coefficient between their expression profiles is higher than a certain cutoff. The resulting connectivity distribution is compatible with a power-law decay with exponent γ ∼ 1, corrected by an exponential cutoff at large connectivity. ...
متن کاملRechecking the Centrality-Lethality Rule in the Scope of Protein Subcellular Localization Interaction Networks
Essential proteins are indispensable for living organisms to maintain life activities and play important roles in the studies of pathology, synthetic biology, and drug design. Therefore, besides experiment methods, many computational methods are proposed to identify essential proteins. Based on the centrality-lethality rule, various centrality methods are employed to predict essential proteins ...
متن کاملA Combination Method of Centrality Measures and Biological Properties to Improve Detection of Protein Complexes in Weighted PPI Networks
Introduction: In protein-protein interaction networks (PPINs), a complex is a group of proteins that allows a biological process to take place. The correct identification of complexes can help better understanding of the function of cells used for therapeutic purposes, such as drug discoveries. One of the common methods for identifying complexes in the PPINs is clustering, but this study aimed ...
متن کاملA Combination Method of Centrality Measures and Biological Properties to Improve Detection of Protein Complexes in Weighted PPI Networks
Introduction: In protein-protein interaction networks (PPINs), a complex is a group of proteins that allows a biological process to take place. The correct identification of complexes can help better understanding of the function of cells used for therapeutic purposes, such as drug discoveries. One of the common methods for identifying complexes in the PPINs is clustering, but this study aimed ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2001
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35075138