Let-7 microRNAs are developmentally regulated in circulating human erythroid cells
نویسندگان
چکیده
منابع مشابه
Let-7 microRNAs and Opioid Tolerance
This chapter will focus on the role of microRNAs (miRs) in regulating the actions of opioid drugs through the opioid receptors. Opioids, such as morphine, are analgesics that are used for treating many forms of acute and chronic pain. However, their chronic use is limited by undesirable effects such as opioid tolerance. The μ opioid receptor (MOR) is the primary receptor responsible for opioids...
متن کاملIdentification of let-7-regulated oncofetal genes.
MicroRNAs (miRNA) are small RNA molecules of approximately 20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, sugge...
متن کاملSpecific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells
Within the last two decades, the incidence of invasive fungal infections has been significantly increased. They are characterized by high mortality rates and are often caused by Candida albicans and Aspergillus fumigatus. The increasing number of infections underlines the necessity for additional anti-fungal therapies, which require extended knowledge of gene regulations during fungal infection...
متن کاملMolecular Basis for Interaction of let-7 MicroRNAs with Lin28
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression. Among these, members of the let-7 miRNA family control many cell-fate determination genes to influence pluripotency, differentiation, and transformation. Lin28 is a specific, posttranscriptional inhibitor of let-7 biogenesis. We report crystal structures of mouse Lin28 in complex with sequences from let-7d, let-...
متن کاملThe imprinted H19 lncRNA antagonizes let-7 microRNAs.
Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19 long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer. However, how H19 acts to regulate gene function has remained enigmatic, despite the recent implication of its encoded miR-675 in limiting placental growth. We noted that vertebrate H19 harbors both canonical and noncanon...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2009
ISSN: 1479-5876
DOI: 10.1186/1479-5876-7-98