Lesion Biomarkers of Aging in B6C3F1 Hybrid Mice

Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice

We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2-9 months), middle (22-23 months) and old (33-46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44+ cells in blood, spleen and bone marrow in old PL mice th...

RDX and miRNA Expression in B6C3F1 Mice

The Effect of Peripheral Injection of Leptin on Biomarkers of Aging in Calorie Restricted Rats

Background and Objectives: Calorie restriction (CR) is one of the proven methods of extending lifespan and slowing aging. Leptin is a nutritionally regulated adipokine that has been proposed as a possible key signal in the adaptive responses relevant to CR. Under CR, plasma leptin levels decrease, thus it was hypothesized that leptin administration may counteract CR-induced weight loss. Therefo...

Studies of carcinogenicity of sodium chlorite in B6C3F1 mice.

The carcinogenic activities of sodium chlorite in B6C3F1 mice were examined. Sodium chlorite was given at concentrations of 0 (control), 0.025% (low dose), or 0.05% (high dose) in the drinking water of 150 female and 150 male mice for 80 weeks, after which time the animals were returned to distilled water without sodium chlorite. All mice were sacrificed 85 weeks from the beginning of the exper...

Nine cases of granular cell tumors in B6C3F1 mice.

The histological characteristics of 9 cases of granular cell tumors (GCTs) observed in B6C3F1 mice were examined to determine their cellular origin. Seven of the 9 cases were found in the uterus and other 2 cases were in the subcutaneous tissue. Tumor cells had abundant granules in the cytoplasm which were stained with PAS and were resistant to diastase treatment. Ultrastructurally, the granule...