Leptin in human physiology and therapeutics

Leptin in human physiology and pathophysiology.

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted hormone with pleiotropic effects in the physiology and pathophysiology of energy homeostasis, endocrinology, and metabolism. Studies in vitro and in animal models highlight the potential for leptin to regulate a number of physiological functions. Available evidence from human studies indicates that leptin has a...

The role of leptin in human physiology and pathophysiology.

This review focuses on current knowledge of leptin biology and the role of leptin in various physiological and pathophysiological states. Leptin is involved in the regulation of body weight. Serum leptin can probably be considered as one of the best biological markers reflecting total body fat in both animals and humans. Obesity in man is accompanied by increased circulating leptin concentratio...

Modern Therapeutics 2012: Advances in Physiology, Pharmacology and Pharmaceutical Sciences

S MODERN THERAPEUTICS 2012 J Popul Ther Clin Pharmacol Vol 19(2):e259-e299; August 1, 2012 © 2012 Canadian Society of Pharmacology and Therapeutics. All rights reserved. e260 MODERN THERAPEUTICS 2012: ADVANCES IN PHYSIOLOGY, PHARMACOLOGY AND PHARMACEUTICAL SCIENCES

The function of leptin in nutrition, weight, and physiology.

Recent advances indicate that a robust physiologic system acts to maintain relative constancy of weight in mammals. A key component of this system is leptin. Leptin is an adipocyte hormone that functions as the afferent signal in a negative feedback loop regulating body weight. In addition, leptin functions as a key link between nutrition and the function of most, if not all other physiologic s...

The Physiology and Therapeutics of the Harrogate Waters