Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort
نویسندگان
چکیده
منابع مشابه
Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort.
Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the Europ...
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15 صفحه اولSerum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.
BACKGROUND Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody ...
متن کاملMeat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition.
BACKGROUND Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing. METHODS We prospectively followed 478 040 men and women from 10 European countries who were free of cancer at enrollment between 1992 and 1998. Information on diet and lifesty...
متن کاملRe: Meat, fish, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition.
In a large cohort comprising 10 populations in the European Prospective Investigation into Cancer and Nutrition, Norat et al. ( 1 ) reported that processed and red meat intake was associated with elevated rates of colorectal cancer and its subtypes. Although the authors considered several study limitations, they may have omitted one that is key: the possibility that confounding by socioeconomic...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2012
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-12-0465