Leishmania braziliensis prostaglandin F2α synthase impacts host infection
نویسندگان
چکیده
منابع مشابه
The immunobiology of Leishmania braziliensis infection
Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania that affect millions of people worldwide. These diseases are caused by distinct Leishmania species, of which L. braziliensis, a New World representative of the Leishmania genus, has been the least studied. Although leishmaniasis caused by L. braziliensis induces a range of clinical manifestations ranging from mild ...
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Members of the genus Trypanosoma cause African trypanosomiasis in humans and animals in Africa. Infection of mammals by African trypanosomes is characterized by an upregulation of prostaglandin (PG) production in the plasma and cerebrospinal fluid. These metabolites of arachidonic acid (AA) may, in part, be responsible for symptoms such as fever, headache, immunosuppression, deep muscle hyperae...
متن کاملMacrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
BACKGROUND Leishmania preferentially infects macrophages, which allow the parasite to multiply but can also kill the parasite. Although the T cell response in human leishmaniasis is well-characterized, little is known about the concomitant macrophage behavior. The aim of this study was to characterize the macrophage immune response after Leishmania braziliensis infection in cells derived from c...
متن کاملNeutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection.
Neutrophils play an active role in the control of infections caused by intracellular pathogens such as Leishmania. In the present study, we investigated the effect of neutrophil depletion at the time of Leishmania braziliensis infection of BALB/c mice and how neutrophils interact with the infected macrophage to promote parasite elimination. The in vivo depletion of neutrophils led to a signific...
متن کاملEnhanced Leishmania braziliensis Infection Following Pre-Exposure to Sandfly Saliva
BACKGROUND Sand fly saliva has an array of pharmacological and immunomodulatory components, and immunity to saliva protects against Leishmania infection. In the present study, we have studied the immune response against Lutzomyia intermedia saliva, the main vector of Leishmania braziliensis in Brazil, and the effects of saliva pre-exposure on L. braziliensis infection employing an intradermal e...
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ژورنال
عنوان ژورنال: Parasites & Vectors
سال: 2020
ISSN: 1756-3305
DOI: 10.1186/s13071-020-3883-z