Left ventricular morphology in patients with aortic coarctation and bicuspid aortic valve: novel insights from a statistical shape modelling framework

نویسندگان

چکیده

Abstract Background The functional implications of left ventricular (LV) morphological characterization in congenital heart disease (CHD) are not widely explored. Purpose This study qualitatively and quantitatively assessed LV shape associations with a) function b) thoracic aortic morphology patients coarctation (CoA) with/without bicuspid valve (BAV). Methods A statistical modelling (SSM) framework was employed to analyse three-dimensional (3D) shapes from cardiac magnetic resonance (CMR) imaging data n=110 cases including: isolated CoA (n=25), CoA+BAV (n=30), BAV age-matched healthy controls (n=25). Average 3D templates (Picture 1) deformations were computed. Correlations between CMR-derived morphometric parameters (i.e. sphericity, conicity) as well global apical strain values elucidate possible implications. relationship features arch architecture gothicity, tortuosity) also explored by means regression analysis. Results template shorter more spherical patient 1), confirmed analysis the SSM-derived modes. which higher CoA, associated (p≤0.04) lower longitudinal, radial circumferential strain, irrespective presence stenosis and/or regurgitation. Conversely, neither nor architecture. Conclusions Differences observed patients. Increasing sphericity reduced independent disease. Funding Acknowledgement Type funding sources: Foundation. Main source(s): British Heart Foundation NIHR BRC

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ژورنال

عنوان ژورنال: European Heart Journal

سال: 2022

ISSN: ['2634-3916']

DOI: https://doi.org/10.1093/eurheartj/ehac544.261