Lectin Galactoside-Binding Soluble 3 Binding Protein (LGALS3BP) is a Cancer-Associated Ligand for Inhibitory Siglecs
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منابع مشابه
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP, also called Mac-2 binding protein) is a heavily glycosylated secreted molecule that has been shown previously to be up-regulated in many cancers and has been implicated in tumor metastatic processes, as well as in other cell adhesion and immune functions. The CD33-related subset of sialic acid-binding immunoglobulin-like lectins (S...
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Accumulating evidence indicates that serum and tissue levels of lectin, galactoside-binding soluble 3 binding protein (LGALS3BP), a secreted glycoprotein, are elevated in human cancers. Recently, we have identified LGALS3BP as a factor capable of stimulating angiogenesis of microvascular endothelial cells in vitro as well as in vivo. However, the potential therapeutic implications of LGALS3BP f...
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W. Mark ABBOTT,* Andrew MELLOR,t Yvonne EDWARDS$ and Ten FEIZI*§ *Section of Glycoconjugate Research, M.R.C. Clinical Research Centre, Watford Road, Harrow, Middx. HAl 3UJ, tDivision of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, and TMRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, Wolfson House, 4 Stephens...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2014
ISSN: 0923-7534
DOI: 10.1093/annonc/mdu467.8