Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage
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چکیده
منابع مشابه
Leaky lysosomes in lung transplant macrophages: azithromycin prevents oxidative damage
BACKGROUND Lung allografts contain large amounts of iron (Fe), which inside lung macrophages may promote oxidative lysosomal membrane permeabilization (LMP), cell death and inflammation. The macrolide antibiotic azithromycin (AZM) accumulates 1000-fold inside the acidic lysosomes and may interfere with the lysosomal pool of Fe. OBJECTIVE Oxidative lysosomal leakage was assessed in lung macrop...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2012
ISSN: 1465-9921
DOI: 10.1186/1465-9921-13-83