Lead optimization of dual tubulin and Hsp27 inhibitors
نویسندگان
چکیده
منابع مشابه
Lead optimization of dual tubulin and Hsp27 inhibitors.
Tubulin and heat shock protein 27 (Hsp27) are well-characterized molecular targets for anti-cancer drug development. We previously identified lead compounds that inhibited both Hsp27 and tubulin. These compounds exhibited extensive anti-cancer activities against the proliferation of various human cancer cell lines. In the current study, a systematic ligand based structural optimization led to n...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2014
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2014.04.038