Lead exposure, brain damage, and adult behavior
نویسندگان
چکیده
منابع مشابه
Adult Lead Exposure: Time for Change
We have assembled this mini-monograph on adult lead exposure to provide guidance to clinicians and public health professionals, to summarize recent thinking on lead biomarkers and their relevance to epidemiologic research, and to review two key lead-related outcomes, namely, cardiovascular and cognitive. The lead standards of the U.S. Occupational Safety and Health Administration are woefully o...
متن کاملExposure to lead and the developmental origin of oxidative DNA damage in the aging brain.
Oxidative damage to DNA has been associated with neurodegenerative diseases. Developmental exposure to lead (Pb) has been shown to elevate the Alzheimer's disease (AD) related beta-amyloid peptide (Abeta), which is known to generate reactive oxygen species in the aging brain. This study measures the lifetime cerebral 8-hydroxy-2'-deoxyguanosine (oxo8dG) levels and the activity of the DNA repair...
متن کاملOrganic brain damage and occupational solvent exposure.
Three hundred and nine men with organic dementia, cerebral atrophy, or psycho-organic syndrome admitted for five nights or more to one of 18 Quebec hospitals were individually matched with patients admitted (1) with some other psychiatric diagnosis and (2) to a general hospital. Lifetime occupational histories were obtained by telephone. Occupational exposure to solvents was assessed blind to t...
متن کاملOccupational exposure to lead and induction of genetic damage.
To investigate whether occupational exposure to lead is genotoxic, we evaluated data from 103 lead-exposed workers and 78 matched controls. These data correspond to three different sampling periods, and we measured genetic damage as increases in the frequency of binucleated cells with micronuclei (BNMN) in peripheral blood lymphocytes. The levels of exposure were determined according to the lea...
متن کاملMotor behavior and neural changes following perinatal and adult-onset brain damage: implications for therapeutic interventions.
This article provides information pertaining to recent scientific findings regarding neural and motor development and the effects of brain damage on that development. The article is intended to provide the clinician with new information that will assist in patient assessments and the establishment of therapeutic interventions. Clinical and scientific issues pertaining to perinatal and adult-ons...
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ژورنال
عنوان ژورنال: Environmental Science & Technology
سال: 2008
ISSN: 0013-936X,1520-5851
DOI: 10.1021/es087182y