LDL particle size: an important drug target?

Ldl Particle Size: Does It Matter?

ldl particle size and reactive oxygen metabolites in dyslipidemic patients

objectives: small dense low‑density lipoprotein (sdldl) which has a small ldl particle size with greater susceptibility to oxidation is regarded as a risk marker for cardiovascular disease. the diacron reactive oxygen metabolites (d‑roms) test has recently been introduced as an oxidative stress‑related marker in the clinic. the aim of the present study was to investigate the correlation between...

LDL particle size distribution. Results from the Framingham Offspring Study.

Using 2-16% gradient gel electrophoresis, we examined low density lipoprotein (LDL) particle size in relation to plasma lipoproteins in 1,168 women and 1,172 men from the Framingham Offspring Study. In addition, we studied the effect of dietary intake on LDL size in a subset of the population. Seven LDL size peaks were identified, with the largest, LDL 1, being found in the density range 1.019-...

LDL Particle Size and Reactive Oxygen Metabolites in Dyslipidemic Patients

OBJECTIVES Small dense low-density lipoprotein (sdLDL) which has a small LDL particle size with greater susceptibility to oxidation is regarded as a risk marker for cardiovascular disease. The diacron reactive oxygen metabolites (d-ROMs) test has recently been introduced as an oxidative stress-related marker in the clinic. The aim of the present study was to investigate the correlation between ...

The Metabolic Syndrome , LDL Particle Size , and Atherosclerosis

An operative definition of the metabolic syndrome has been suggested by a working group associated with the World Health Organization in 1998. The aim of this study was to examine whether small, low density lipoprotein (LDL) particle size was associated with the metabolic syndrome and with subclinical atherosclerosis as measured by ultrasound in the carotid and femoral arteries. The study was p...