LB977 NK cells in the pathogenesis of hidradenitis suppurativa (HS)

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with deep-seated lesions in the apocrine gland areas of body. Recruitment and activation innate adaptive immune cells around hair follicles drive initiation progression HS; however, nature cell populations underlying mechanisms remain unclear. scRNAseq revealed that NK CD4 T were major lymphocyte HS. Confocal microscopy showed HS, but not normal skin, contained elevated numbers CD56dim CD3+CD56bright cells. These classical highly cytolytic primarily within epidermis sinus tracts HS they expressed high levels perforin granzyme A. In contrast, (NK-T cells) restricted to tracts. The NK-T associated α-SMA expressing enriched fibroblasts, feature fibrosis. Notably, also CD2, receptor signals augmented activity increased production IFN-γ. keratinocytes CD58 (LFA-3), counter-receptor for CD2. IL-15 IL-18; cytokines induced after engagement miR150 miR155, micro RNAs necessary maturation cytotoxicity, respectively. To test CD2 blockade will be beneficial, from patients cultured presence anti-CD2 mAb or control IgG. led significant decrease HS-associated (IL-6, IL-15, IL-18, IFN-γ) chemokines (IL-8, MIP1α, RANTES, IP10). sum, this study show distinct are contributors as well fibrosis likely viable novel therapy