LB951 Assessing penetration, delivery, and mode of action of dissolving microneedle patches for reducing under-eye wrinkles using reflectance confocal microscopy

The purpose of this study was to visualize penetrance self dissolving microneedles into different layers the epidermis, subsurface anatomical changes and calculate distance between deposition drugs in dermis. We recruited 8 subjects age groups better understand how microneedling patches containing hyaluronic acid botulinum polypeptide-1 work under eye reduce wrinkles. Clinical pictures were taken reflectance confocal microscopy (RCM) performed before application after removal patch view changes. Each left for at least 6 hours overnight performing a scan. In 1 subject, we hour 2 mode action microneedle patches. able area penetration epidermis. Distance calculated. clearly dermis 3 subjects, as well subject that confocaled sequentially hours. Dissolving allow targeted drug delivery are available over counter various aesthetic reasons, including RCM can be useful tool delivery. Furthermore, it help determine which areas skin would ideal transdermal