LB873 Neuroblast differentiation-associated protein derived polypeptides: AHNAK(5758-5775) induced inflammatory reaction by activation mast cells via ST2

Mast cells significantly increase and activate in psoriasis lesions are involved psoriatic inflammation. Neuroblast differentiation-associated protein (AHNAK) mainly express skin, esophagus, kidney other organs, which participates the differentiation of neurons, formation cytoskeletal structure muscular regeneration, calcium homeostasis process. Whether AHNAK is mast cell activation unclear, mechanisms AHNAK-induced skin inflammation also need investigation. To investigate whether derived polypeptides: AHNAK(5758-5775) activates induces contributing to psoriasis. Wild-type mice were treated with observe inflammatory infiltration cytokines release vivo. Release mediators by mouse primary LAD2 measured vitro. The receptor was demonstrated molecular docking analysis, dynamics simulation siRNA transfection. could cause reaction induce WT mice, ST2 may be a key mediating effect on leading cytokine release. might participate onset development