LB871 β-Tryptase promotes inflammatory response in psoriasis by activating keratinocytes

Mast cells (MCs) is an effector in inflammatory skin diseases by secreting potent mediators. It has been proved that MCs significantly increase and activate the lesions of psoriasis patients, which can be activated external factors a variety endogenous mediators to participate pathological changes formation microenvironment psoriasis. Current studies suggest axis activation releasing factors, such as TNF-α IL-17. also play important role T differentiation cell recruitment. However, largest specific releases MCs, whether β-tryptase show not reported. In our present study, we detected level mediator patients normal immunohistochemical staining, immunofluorescent staining ELISA. The results showed was significant upregulation positively correlated with epidermis thickening level. Moreover, analysis imiquimod mouse model same results. addition, keratinocytes (KCs) co-culture vitro study executed could promote KCs proliferation induced release. Intervention antagonist inhibit activation. Our provides evidence release might key medium induces activation, shows pathology response