Late‐Stage Functionalization for the Divergent Synthesis of Podophyllotoxin Derivatives by Rhodium Catalysis

A rhodium-catalyzed methodology leads to four kinds of novel podophyllotoxin derivatives starting from readily available in a late-stage functionalization strategy. Some them are found show excellent anticancer activity. This direct C−H can be expressed the (roots podophyllum species) being converted into (leaves) by rhodium catalysis. More information Research Article C. Li, H. Liu and co-workers (DOI: 10.1002/chem.202300960).