منابع مشابه
Late Stage Infection in Sleeping Sickness
At the turn of the 19(th) century, trypanosomes were identified as the causative agent of sleeping sickness and their presence within the cerebrospinal fluid of late stage sleeping sickness patients was described. However, no definitive proof of how the parasites reach the brain has been presented so far. Analyzing electron micrographs prepared from rodent brains more than 20 days after infecti...
متن کاملNifurtimox plus Eflornithine for Late-Stage Sleeping Sickness in Uganda: A Case Series
BACKGROUND We report efficacy and safety outcomes from a prospective case series of 31 late-stage T.b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+E) in Yumbe, northwest Uganda in 2002-2003, following on a previously reported terminated trial in nearby Omugo, in which 17 patients received the combination ...
متن کاملEstimates of the duration of the early and late stage of gambiense sleeping sickness
BACKGROUND The durations of untreated stage 1 (early stage, haemo-lymphatic) and stage 2 (late stage, meningo-encephalitic) human African trypanosomiasis (sleeping sickness) due to Trypanosoma brucei gambiense are poorly quantified, but key to predicting the impact of screening on transmission. Here, we outline a method to estimate these parameters. METHODS We first model the duration of stag...
متن کاملRandomized, controlled trial of treatments for second-stage sleeping sickness.
clinically valuable for prediction of TB treatment outcome on an individual basis, which will be necessary to detect improvement over the current treatment protocol with its recurrence rate of around 5%. We believe the inclusion of host factors could increase sensitivity over microbio-logical testing alone, particularly as the majority of patients with TB are sputum culture negative after 3 mon...
متن کاملSleeping Sickness Wakes Again
Sleeping sickness of horses was, as reeentiy as the IQSO's, the most devastating livestock disease in the United States. Horses died by the hundreds of thousands in the Midwestern United States, in California, and along the Atlantic seaboard at a period which coincided with the beginning of the sharp decline in the use of horses on the farm. Losses were so severe in some areas that the inevitab...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0034304