Late anthracycline cardiotoxicity after childhood cancer
نویسندگان
چکیده
منابع مشابه
Prospective longitudinal assessment of late anthracycline cardiotoxicity after childhood cancer: the role of diastolic function.
A nthracyclines are highly effective in the treatment of childhood malignancies, but are potentially cardiotoxic at all dose ranges. Early studies suggested that as many as 65% of acute lymphoblastic leukaemia (ALL) survivors have subclinical abnormalities of left ventricular (LV) systolic function at medium term follow up. More recent reports have shown that the prevalence of cardiac abnormali...
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Anthracyclines are among the most active agents for the treatment of breast cancer; their use in combination regimens improves both disease-free and overall survival in patients with breast cancer. Unfortunately, the clinical utility of anthracycline use is limited by a cumulative dose-dependent cardiac toxicity resulting in congestive heart failure. As methods for detecting and treating breast...
متن کاملLate cardiotoxicity after low dose of anthracycline therapy for acute lymphoblastic leukemia in childhood
INTRODUCTION Late cardiotoxicity is a known complication of anthracycline therapy but the long-term effects of low cumulative doses are not well documented. We studied late cardiotoxicity in survivors of childhood acute lymphoblastic leukemia (ALL) treated with low anthracycline doses 10 to 20 years earlier. METHODS Seventy-seven ALL survivors who received a cumulative anthracycline dose <250...
متن کاملOccult cardiotoxicity in childhood cancer survivors exposed to anthracycline therapy.
BACKGROUND More than 50% of >270 000 childhood cancer survivors in the United States have been treated with anthracyclines and are therefore at risk of developing cardiotoxicity. Cardiac magnetic resonance (CMR) has demonstrated utility to detect diffuse interstitial fibrosis and changes in regional myocardial function. We hypothesized that CMR would identify occult cardiotoxicity characterized...
متن کاملP53 inhibition exacerbates late-stage anthracycline cardiotoxicity.
AIMS Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acute and late-stage cardiotoxicity. Children are particularly sensitive to DOX-induced heart failure. Here, the impact of p53 inhibition on acute vs. late-stage DOX cardiotoxicity was examined in a juvenile model. METHODS AND RESULTS Two-week-old MHC-CB7 mice (which express dominant-interfering p53 in...
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ژورنال
عنوان ژورنال: Cancer
سال: 2003
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.11274