Lasers for matrix‐assisted laser desorption ionization

Fundamentals of matrix-assisted laser desorption/ionization mass spectrometry with pulsed infrared lasers

The fundamental work and current knowledge on the mechanisms of matrix-assisted laser desorption ionization with pulsed infrared lasers is reviewed and discussed, with a special emphasis on the work performed in the laboratory of the authors in the recent past. The role of the different relevant irradiation parameters (laser wavelength, laser pulse duration, irradiated area and laser fluence) a...

Infrared laser desorption/ionization on silicon.

Laser desorption/ionization from a single-crystal silicon surface was performed using a laser operating in the 3-microm region of the mid-infrared. Analyte molecules up to 6 kDa were ionized with no added matrix. As with ultraviolet desorption/ionization from porous silicon (DIOS), IR laser desorption from silicon does not produce matrix ions that can interfere with analysis of low-mass analyte...

Matrix-Assisted Laser Desorption/Ionization (MALDI)

Matrix Assisted Laser Desorption Ionization Time

Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic review s. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts w ithin the time allow ed. Rapid responses should be considered along w ith other types of information and health care considerations. The information i...

Desorption/ionization efficiency of peptides containing disulfide bonds in matrix-assisted laser desorption/ionization mass spectrometry.

In order to elucidate the role of desorption/ionization efficiency of peptides in MALDI-MS, we focused on peptides with disulfide bonds, which form a rigid tertiary structure. We synthesized seven sets of peptides with one disulfide bond (oxytocin, somatostatin, [Arg(8)]-vasopressin, [Arg(8)]-vasotocin, cortistatin, melanin-concentrating hormone, urotensin II-related peptide) and five sets of ...