Large Genetic Animal Models of Huntington's Disease
نویسندگان
چکیده
منابع مشابه
Large genetic animal models of Huntington's Disease.
The dominant nature of the Huntington's disease gene mutation has allowed genetic models to be developed in multiple species, with the mutation causing an abnormal neurological phenotype in all animals in which it is expressed. Many different rodent models have been generated. The most widely used of these, the transgenic R6/2 mouse, carries the mutation in a fragment of the human huntingtin ge...
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ژورنال
عنوان ژورنال: Journal of Huntington's Disease
سال: 2013
ISSN: 1879-6397
DOI: 10.3233/jhd-130050