Langerhans cells from human oral epithelium are more effective at stimulating allogeneic T cells in vitro than Langerhans cells from skin
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چکیده
منابع مشابه
Langerhans Cells in Skin Lesions of Leprosy
Background: Langerhans cells are important in the pathogenesis of leprosy. A recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. Objective: To investigate a possible relationship between the number of Langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. Methods: An immunohistochemical staining for S100 prot...
متن کاملLangerhans cells derived from genetically modified human CD34+ hemopoietic progenitors are more potent than peptide-pulsed Langerhans cells for inducing antigen-specific CD8+ cytolytic T lymphocyte responses.
Sustained Ag expression by human dendritic cells (DCs) is an attractive means of optimizing Ag presentation for stimulating durable cellular immunity. To establish proof of principle, we used Langerhans cell (LC) progeny of retrovirally transduced CD34(+) hemopoietic progenitor cells to stimulate responses against the HLA-A*0201-restricted influenza matrix peptide (fluMP). Retroviral transducti...
متن کاملHuman epidermal Langerhans cells replenish skin xenografts and are depleted by alloreactive T cells in vivo.
Epidermal Langerhans cells (LC) are potent APCs surveying the skin. They are crucial regulators of T cell activation in the context of inflammatory skin disease and graft-versus-host disease (GVHD). In contrast to other dendritic cell subtypes, murine LC are able to reconstitute after local depletion without the need of peripheral blood-derived precursors. In this study, we introduce an experim...
متن کاملlangerhans cells in skin lesions of leprosy
background: langerhans cells are important in the pathogenesis of leprosy. a recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. objective: to investigate a possible relationship between the number of langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. methods: an immunohistochemical staining for s100 ...
متن کاملIdentification of Langerhans cells in human gingival epithelium.
The purpose of this study was to qualitatively compare three recent techniques of Langerhans cells detection in oral epithelium and to quantitatively compare Langerhans cells in clinically normal and clinically inflamed human gingival biopsies. Eleven subjects were selected who displayed chronic periodontitis and moderate gingival inflammation. A quadrant associated with clinically inflamed tis...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 2004
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.2004.02469.x