منابع مشابه
Recent landmark trials in cardiology.
Oral anticoagulants are a standard of care in patients with thromboembolic events, yet about 20% of patients with unprovoked venous thromboembolism have a recurrence of such events within 2 years after the withdrawal of oral anticoagulant therapy. Extending anticoagulation prevents recurrences but is associated with an increased risk of bleeding. The benefit of aspirin beyond the recommended du...
متن کاملPrevention of Diabetes Complications- Clinical Evidence from Landmark Trials
Introduction T epidemic of type 2 diabetes is a growing public health problem that threatens to reduce life expectancy and increase morbidity as a result of its complications. Hyperglycemia, the cardinal feature of diabetes, can be controlled either by the exogenous administration of insulin or through oral antidiabetic drugs which increase insulin secretion, improve insulin sensitivity or redu...
متن کاملImpact of recent landmark clinical trials on hypertension treatment
High blood pressure remains an important global cause of cardiovascular morbidity and mortality. Strategies for treating hypertension continue to change as new evidence becomes available from clinical drug trials or observational studies on hypertension treatment. As new hypertension guidelines become available, the impact of these trials become evident from changes in the recommendations of tr...
متن کاملBlindness in Randomized Controlled Trials
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
متن کاملThe 1959 meeting in Vienna on controlled clinical trials - A methodological landmark.
At the end of the 1950s, the Council for International Organizations of Medical Sciences (CIOMS) organised a meeting under the joint auspices of the UN Educational, Scientific and Cultural Organisation (UNESCO) and the World Health Organization (WHO), ‘to discuss the principles, organization and scope of ‘controlled clinical trials’, which must be carried out if new methods or preparations used...
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ژورنال
عنوان ژورنال: Heart India
سال: 2018
ISSN: 2321-449X
DOI: 10.4103/heartindia.heartindia_12_18