منابع مشابه
Lamins position the nuclear pores and centrosomes by modulating dynein
Lamins, the type V nuclear intermediate filament proteins, are reported to function in both interphase and mitosis. For example, lamin deletion in various cell types can lead to an uneven distribution of the nuclear pore complexes (NPCs) in the interphase nuclear envelope, whereas deletion of B-type lamins results in spindle orientation defects in mitotic neural progenitor cells. How lamins reg...
متن کاملDisruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling
The accumulation of prelamin A is linked to disruption of cellular homeostasis, tissue degeneration and aging. Its expression is implicated in compromised genome stability and increased levels of DNA damage, but to date there is no complete explanation for how prelamin A exerts its toxic effects. As the nuclear lamina is important for DNA replication we wanted to investigate the relationship be...
متن کاملLamins
Xie and Burke discuss the roles of lamins in nuclear morphology and the pathological consequences of defects in these nuclear envelope proteins.
متن کاملLamins for differentiation
O n page 83, Dorner et al. report that overexpression of a lamina-associated pro tein slows cell proliferation and promotes differentiation in vitro. The fi ndings suggest that laminopathy symptoms may not be due to structural weakness in the tissue, but rather to a failure of stem cells to properly regenerate damaged or aging tissues. A-type lamins are found at the nuclear periphery and in the...
متن کاملLamins at a glance.
Lamins, the major components of the nuclear lamina, have gained rapidly increasing interest over the past decade as lamin mutations were found to cause numerous devastating diseases. These laminopathies include Emery–Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy type 1A, limb-girdle muscular dystrophy type 1B, familial partial lipodystrophy (FPLD), Charcot–Marie–Tooth disease type ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1812iti4