Lacosamide and myoclonic seizures: what is the risk of aggravation?

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Lacosamide treatment of juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy is the most common form of idiopathic generalized epilepsy with onset at puberty or late teenage years. About 80-90% of patients with juvenile myoclonic epilepsy respond to appropriate antiepileptic treatment and achieve seizure freedom, and about 15% of patients become intractable. Valproic acid, levetiracetam, lamotrigine, topiramate and zonisamide are used as firs...

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Myoclonus refers to sudden, brief, shock-like involuntary movements, caused by muscular contractions (positive myoclonus) or inhibitions (negative myoclonus) arising from the central nervous system. This definition excludes the muscular twitches or fasciculation due to lesions of the lower motor neurons. 1 Myoclonus has been observed in patients with various neurological conditions including ep...

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Propofol-related myoclonic seizures

Propofol is a popular agent for induction and maintenance of anaesthesia, as well as an excellent sedative agent widely used in ambulatory anaesthesia. Although involuntary movements due to propofol are well known, the occurrence of propofol-related seizure activity in patients with no previous history of epilepsy is less well highlighted. These seizures may occur at all stages of anaesthesia: ...

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Levetiracetam-associated aggravation of myoclonic seizure in children

Some antiepileptic drugs (AEDs) have been reported to aggravate generalized seizures. We have seen three children whose myoclonic seizures increased on starting treatment with Levetiracetam. In all seizures aggravation was temporally associated to the introduction of the drug. All became seizure-free on withdrawal of levetiracetam with a switch to an alternative antiepileptic drug and this pers...

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ژورنال

عنوان ژورنال: Neurologia i Neurochirurgia Polska

سال: 2021

ISSN: 1897-4260,0028-3843

DOI: 10.5603/pjnns.a2021.0008