Lack of the peroxiredoxin 6 gene causes impaired spatial memory and abnormal synaptic plasticity
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چکیده
منابع مشابه
Protective effect of α-terpineol against impairment of hippocampal synaptic plasticity and spatial memory following transient cerebral ischemia in rats
Objective(s): Cerebral ischemia is often associated with cognitive impairment. Oxidative stress has a crucial role in the memory deficit following ischemia/reperfusion injury. α-Terpineol is a monoterpenoid with anti-inflammatory and antioxidant effects. This study was carried out to investigate the effect of α-terpineol against memory impairment following cerebral ischemia in rats. Materials a...
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Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease patients often exhibit cognitive deficits before the onset of classical symptoms. To investigate the possibility that changes in synaptic plasticity might underlie cognitive ...
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متن کاملIntegrin requirement for hippocampal synaptic plasticity and spatial memory.
The establishment of memory requires coordinated signaling between presynaptic and postsynaptic terminals in the CNS. The integrins make up a large family of cell adhesion receptors that are known to mediate bidirectional signaling between cells or between cells and their external environment. We show here that many different integrins, including alpha3 and alpha5, are expressed broadly in the ...
متن کاملEthanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons
Background and Objective: Ethanol has undesirable effects on memory and synaptic communication. However, its impact on the learned spatial memory is unclear. We investigated the damaging effects of ethanol on place neurons of rat’s hippocampal CA1.Materials and Methods: Sixty four male Wistar rats (250 g) were administered high (1-8 g/kg) or low (0.05-0.1 g/kg) doses of ethanol intraperit...
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ژورنال
عنوان ژورنال: Molecular Brain
سال: 2021
ISSN: 1756-6606
DOI: 10.1186/s13041-021-00779-6