Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects
نویسندگان
چکیده
منابع مشابه
Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects.
Previous studies in HIV patients have reported autoantibodies to several human proteins, including erythropoietin (EPO), interferon-α (IFN-α), interleukin-2 (IL-2), and HLA-DR, as potential mediators of anemia or immunosuppression. The etiology of these autoantibodies has been attributed to molecular mimicry between HIV epitopes and self-proteins. Here, the Luciferase Immunoprecipitation System...
متن کاملHIV and Molecular Mimicry
For more than three decades, molecular mimicry has been considered a contributing factor in viral pathogenesis. The phenomenon comes about when viral antigens share epitopes with host cell proteins. Because tolerance is thought never to be complete, the mimicking microbe can induce anti-self antibodies, a state of autoimmunity, with resulting immunopathogenesis. This mode of attack seems preemi...
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INTRODUCTION The aim of this study was to determine factors associated with lack of serological response (LSR) to treatment of syphilis among HIV-infected subjects. MATERIALS AND METHODS Retrospective, longitudinal study on HIV-infected subjects diagnosed and treated for syphilis and with an assessable serological response between 1 January 2004 and 15 September 2013. LSR was defined as a <4-...
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Background:In some countries, one of the first and most common manifestations of HIV positive patients is tuberculosis (TB). HIV positive people are prone to other infections such as tuberculosis due to immune deficiency and reduced CD4+ cell count. Although increasing access to antiretroviral therapy has led to a reduction in HIV-related opportunistic infections and mortality, the simultaneous...
متن کاملGastrointestinal immune responses in HIV infected subjects.
The gut associated lymphoid tissue is responsible for specific responses to intestinal antigens. During HIV infection, mucosal immune deficiency may account for the gastrointestinal infections. In this review we describe the humoral and cellular mucosal immune responses in normal and HIV-infected subjects.
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0127662