Labeling Changes for Vinca Alkaloid Chemotherapies
نویسندگان
چکیده
منابع مشابه
Energetics of vinca alkaloid interactions with tubulin isotypes: implications for drug efficacy and toxicity.
A number of vinca alkaloids, including vincristine, vinblastine, and vinorelbine, are currently used in cancer chemotherapy. These three vinca alkaloids interact differently with a range of solid and hematologic tumors. To test the possibility that the tubulin isotype composition is an important determinant in antineoplastic efficacy, we determined thermodynamic parameters for vinca alkaloid in...
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High polo-like kinase 1 (PLK1) expression has been linked to poor outcome in neuroblastoma (NB), indicating that it represents a relevant therapeutic target in this malignancy. Here, we identify a synergistic induction of apoptosis by the PLK1 inhibitor BI 2536 and vinca alkaloids in NB cells. Synergistic drug interaction of BI 2536 together with vincristine (VCR), vinblastine (VBL) or vinorelb...
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The treatment of 22 patients with Vincaleukoblastine is described. The main toxic effects were noted at the sites of injection, on the blood, and on the nervous system. Severe granulocytopenia with little or no depression of platelets was noted in nearly all patients. In fifteen of the 22 patients the administration of Vincaleukoblastine had measurable effects on the malignant process. Partial ...
متن کاملInhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class.
A series of Vinca alkaloids were found to block polymerization of crude tubulin extracts of porcine brain in a dose-dependent manner. This appears to be a specific effect occurring at low concentrations of drug. The concentration of vinblastine that prevents polymerization by 50% was 4.3 x 10(-7) mole/liter for a tubulin concentration of 3.0 mg/ml, and this concentration is consistent with leve...
متن کاملInteractions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: a dynamic, kinetic, and spectroscopic study.
The stereoselectivity of the reaction between (R)-(-)-2-butylamine and the diastereomeric proton-bound complexes of (+)-catharanthine (C) or (-)-vindoline (V) with some chiral amido[4]resorcinarenes has been investigated in the gas phase by ESI-FT-ICR-MS. The reaction stereoselectivity (0.56 < k(homo)/k(hetero) < 16.9) is found to depend critically on the functional groups present in the chiral...
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ژورنال
عنوان ژورنال: AJN, American Journal of Nursing
سال: 2021
ISSN: 0002-936X
DOI: 10.1097/01.naj.0000751100.04448.71