La3+ stabilizes the hexagonal II (HII) phase in phosphatidylethanolamine membranes

2-hydroxylated fatty acid derivatives promote and stabilize inverted hexagonal phases in phosphatidylethanolamine membranes

Cellular functions are usually associated with the activity of proteins and nucleic acids. Consequently, human pathologies are classically viewed as malfunctions of these macromolecules. However, recent studies have shown that some lipids can regulate the localization and the activity of membrane proteins (1). 2-hydroxyoleic acid (2-OHOA) also known as Minerval, is a synthetic monounsaturated f...

Determination of L –HII Phase Transition Temperature for 1,2-Dioleoyl-sn-Glycero-3-Phosphatidylethanolamine

The thermodynamic properties of fully-hydrated lipids provide important information about the stability of membranes and the energetic interactions of lipid bilayers with membrane proteins (Nagle and Scott, Physics Today, 2:39, 1978). The lamellar/inverse hexagonal (L –HII) phase transition of 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) water mixtures is a first-order transition a...

Molecular view of hexagonal phase formation in phospholipid membranes.

Important biological processes, such as vesicle fusion or budding, require the cell matrix to undergo a transition from a lamellar to a nonlamellar state. Although equilibrium properties of membranes are amenable to detailed theoretical studies, collective rearrangements involved in phase transitions have thus far only been modeled on a qualitative level. Here, for the first time, the complete ...

Partial dehydration of phosphatidylethanolamine phosphate groups during hexagonal phase formation, as seen by i.r. spectroscopy.

The gel-to-fluid and lamellar-to-HII-hexagonal thermotropic phase transitions of egg-yolk phosphatidylethanolamine have been examined by Fourier-transform infrared spectroscopy under a variety of conditions, namely excess water at pH 5.0, excess water at pH 9.5 and low hydration. The various lamellar and hexagonal phases have been characterized by X-ray diffraction. At pH 5.0, gel-fluid and lam...

The interrelation of phosphatidylethanolamine and glycosyl diglycerides in bacterial membranes.